The Prox1–Vegfr3 feedback loop maintains the identity and the number of lymphatic endothelial cell progenitors
Identifieur interne : 002445 ( Main/Exploration ); précédent : 002444; suivant : 002446The Prox1–Vegfr3 feedback loop maintains the identity and the number of lymphatic endothelial cell progenitors
Auteurs : R. Sathish Srinivasan ; Noelia Escobedo ; Ying Yang ; Ashley Interiano ; Miriam E. Dillard ; David Finkelstein [États-Unis] ; Suraj Mukatira [États-Unis] ; Hyea Jin Gil ; Harri Nurmi [Finlande] ; Kari Alitalo [Finlande] ; Guillermo OliverSource :
- Genes & Development [ 0890-9369 ] ; 2014.
Abstract
The lack of Prox1 activity results in the complete absence of lymphatic endothelial cells (LECs). Here, Srinivasan et al. identified Vegfr3, the cognate receptor of the lymphangiogenic growth factor Vegfc, as a dosage-dependent, direct in vivo target of Prox1. Vegfr3 regulates Prox1 by establishing a feedback loop necessary to maintain the identity of LEC progenitors, and Vegfc-mediated activation of Vegfr3 signaling is necessary to maintain Prox1 expression in LEC progenitors.
Url:
DOI: 10.1101/gad.216226.113
PubMed: 25274728
PubMed Central: 4180978
Affiliations:
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Here, Srinivasan et al. identified Vegfr3, the cognate receptor of the lymphangiogenic growth factor Vegfc, as a dosage-dependent, direct in vivo target of Prox1. Vegfr3 regulates Prox1 by establishing a feedback loop necessary to maintain the identity of LEC progenitors, and Vegfc-mediated activation of Vegfr3 signaling is necessary to maintain Prox1 expression in LEC progenitors.</p></div></front></TEI><affiliations><list><country><li>Finlande</li><li>États-Unis</li></country><region><li>Uusimaa</li></region><settlement><li>Helsinki</li></settlement><orgName><li>Université d'Helsinki</li></orgName></list><tree><noCountry><name sortKey="Dillard, Miriam E" sort="Dillard, Miriam E" uniqKey="Dillard M" first="Miriam E." last="Dillard">Miriam E. Dillard</name><name sortKey="Escobedo, Noelia" sort="Escobedo, Noelia" uniqKey="Escobedo N" first="Noelia" last="Escobedo">Noelia Escobedo</name><name sortKey="Gil, Hyea Jin" sort="Gil, Hyea Jin" uniqKey="Gil H" first="Hyea Jin" last="Gil">Hyea Jin Gil</name><name sortKey="Interiano, Ashley" sort="Interiano, Ashley" uniqKey="Interiano A" first="Ashley" last="Interiano">Ashley Interiano</name><name sortKey="Oliver, Guillermo" sort="Oliver, Guillermo" uniqKey="Oliver G" first="Guillermo" last="Oliver">Guillermo Oliver</name><name sortKey="Srinivasan, R Sathish" sort="Srinivasan, R Sathish" uniqKey="Srinivasan R" first="R. Sathish" last="Srinivasan">R. Sathish Srinivasan</name><name sortKey="Yang, Ying" sort="Yang, Ying" uniqKey="Yang Y" first="Ying" last="Yang">Ying Yang</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Finkelstein, David" sort="Finkelstein, David" uniqKey="Finkelstein D" first="David" last="Finkelstein">David Finkelstein</name></noRegion><name sortKey="Mukatira, Suraj" sort="Mukatira, Suraj" uniqKey="Mukatira S" first="Suraj" last="Mukatira">Suraj Mukatira</name></country><country name="Finlande"><region name="Uusimaa"><name sortKey="Nurmi, Harri" sort="Nurmi, Harri" uniqKey="Nurmi H" first="Harri" last="Nurmi">Harri Nurmi</name></region><name sortKey="Alitalo, Kari" sort="Alitalo, Kari" uniqKey="Alitalo K" first="Kari" last="Alitalo">Kari Alitalo</name><name sortKey="Alitalo, Kari" sort="Alitalo, Kari" uniqKey="Alitalo K" first="Kari" last="Alitalo">Kari Alitalo</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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